But how would you mount a 2.5 inch drive to a little Raspberry Pi computer? Well today I toyed around with some ideas about that.
I took the top off of the JBtek acrylic case I was using with the X850 system...
...and replaced it (and the X850) with a standard 2.5 inch SSD.
The spacing between the rear standoffs was a near perfect match to the SSD mounting holes, and the M3 standoffs screwed right into the drive! Front mounting holes didn't line up with the front of the case, so it's just resting on the standoffs there. I could drill holes under each front standoff to screw them down, but I don't think it's necessary (it feels very secure the way it is). I used a <$10 SATA-USB 3.0 adapter and a <$40 Silicon Power A55 128GB SSD. The final touch was a wire tie to support the bend in the USB cable and reduce mechanical load on the ports.
This is a nice arrangement. The <$10 SATA to USB adapter does work with pure USB boot on the Pi3B (boot and reboot both work fine), and it's a much less expensive system than the X850. The SSD was $10 less, and the SATA-USB adapter was $15 less, for a total savings of $25. That's more than the price difference between the 128GB and 256GB drives! I could have gotten double the storage and still saved money.
It's not that expensive compared to a good SD card, either. The 128GB SanDisk Ultra A1 micro-SD card is the same price as the SSD here, and the 256GB card is actually much more expensive than the 256GB Silicon Power SSD (nearly double the price).
With the X850 I had to extend the length of the standoffs to make room for the drive. With this arrangement it looks like I could use shorter standoffs, but that would make it harder to connect things to the GPIO header (there's plenty of room with the default 35mm standoffs).
Hmm... and that gives me another idea...
Mount the drive to the bottom of the case instead.
This would allow you to use the top of the case with the fan (which I found too noisy, and unnecessary), or install a HAT, or a small LCD screen, or? In this configuration you have full access to the Pi system board to do whatever you want, while still having an SSD mounted to the computer. Though some might argue that it's actually a computer mounted to a 2.5 inch SSD.

EDIT (11/23/2018):
The ELUTENG adapter has been replaced by a newer model that does not work well (links removed because they are no longer valid).
See the following post for more information.
viewtopic.php?f=63&t=227600